Model:7501123011209
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Cardispan Tablets Chewable 1gr 20 Tabs, Levocarnitine
Cardispan TABLETS:
Levocarnitine.
And dosage form:
Each tablet contains:
Levocarnitine ............................. 1 g
Excipient qs 1 tablet .....................
INDICATIONS:
Cardispan * is indicated for the treatment of levocarnitine deficiency, which can be primary (cardiomyopathy, myopathy, inborn errors of metabolism and muscular dystrophy), or secondary, as well as those conditions which are necessary to increase the production of body energy by fatty acid utilization as an energy source. There are secondary levocarnitine deficiency: (1) Lack of synthesis and / or contribution (artificial nutrition, malnutrition and poor eating habits, premature infants and underweight children, infants fed soy or casein formulas, strict vegetarianism, cirrhosis liver). (2) Consumption of levocarnitine (acute and chronic myocardial ischemia: myocardial infarction, angina, congestive heart failure, arrhythmias, myocardiosclerosis, senile heart CABG surgery, peripheral vascular disease and patients in rehabilitation or fitness). (3) Loss of levocarnitine (kidney failure treated with dialysis or hemodialysis hypercatabolic conditions such as sepsis, burns, surgery and major trauma, hyperthyroidism, pregnancy, cardiomyopathy secondary to tricyclic deantidepresivos use, valproic acid or antineoplastic). (4) metabolic and endocrine disorders (diabetes mellitus, diabetic ketoacidosis, hyperlipoproteinemia, endogenous obesity, hypothyroidism, hypopituitarism, Addison's disease and Cushing's syndrome).
Other uses: In sports medicine, levocarnitine is used as a nutritional supplement and ergogenic substance in healthy people doing sports. Because of its role in lipid metabolism, is used as an adjunct to the medical management of weight control in patients with exogenous obesity due to excessive and disordered food intake.
Pharmacokinetics in Humans:
* Levocarnitina Cardispan contains natural constituent of the human body. Only the levorotatory isomer is biologically active. It plays an essential role in metabolism for energy production. The intramitochondrial β-oxidation of fatty acids, is the largest and most efficient source of energy (ATP) but is required to produce the essential transport, levocarnitine, physiological substance that generates energy by transporting fatty acids from the cytosol to the mitochondrial matrix where performs the beta-oxidation production of acetyl coenzyme A and ATP by the citric acid cycle, facilitates the metabolism of carbohydrates and remove toxic compounds from the mitochondria. Therefore, levocarnitine is essential to provide the energy substrate, especially in skeletal muscle and myocardium; deficiency brings about significant changes in lipid metabolism, made possible by a deficient production of energy, for an accumulation of free fatty acids and triglycerides.
Ischemia and intense physical activity causes significant metabolic changes as there is an increase in the energy requirement. Under these conditions occurs a great loss and / or increased demand for metabolic levocarnitina lipid utilization, ketone bodies and amino acid chains. Tissue levocarnitine deficiency in patients with chronic or acute ischemia and in people after physical activity is identified. Levocarnitine is a natural compound that improves cardiovascular function and increases physical performance, improving ergometric evaluations.
When there is an imbalance between the contribution of energy sources and demand for ATP, the energy crisis happens. In children, increased energy demands during growth, sports requirements, periods of fasting, fever, infection and convalescence. Levocarnitine deficiency and energy is manifested by low Somatic index, lack of progress in the development, poor appetite, recurrent infections, apathy, disinterest, lethargy, low athletic performance, weakness and poor muscle development.
Levocarnitine naturally acquired by ingestion of food, especially of animal origin, and can be synthesized in the liver and kidneys from the amino acids lysine and methionine. Levocarnitine is absorbed in the small intestine, mainly in the jejunum. Join the movement and is widely distributed in the body. Its presence in tissues suggests the existence of a cellular system and selective uptake in skeletal muscle myocardium, as well as liver and kidney. Most levocarnitine body is excreted in urine and feces.
CONTRAINDICATIONS:
Hypersensitivity to levocarnitine.
PRECAUTIONS:
Tablets should be chewed to be swallowed. The product has no toxic effects even at doses as high as 15 g per day, as it is a substance that normally exists in the organism. However, higher doses of 5 tablets daily can cause softening of stools or diarrhea.
RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING
There are no restrictions on use during pregnancy and lactation. In fact, the requirements are increased in such conditions. Levocarnitine is a normal component of breast milk.
ADVERSE REACTIONS:
Higher doses of 3 to 5 g per day in adults, is associated with softening the stool and, in some cases, the presence of minor clinical diarrhea. No other adverse events have been reported with administration of levocarnitine.
DRUG INTERACTIONS AND OTHER GENDER:
Have not been reported to date.
CHANGES IN RESULTS OF LABORATORY TESTS
Have not been reported to date.
PRECAUTIONS IN RELATION TO EFFECTS OF CARCINOGENESIS, MUTAGENESIS, Impairment of Fertility
Studies have shown that levocarnitine is not mutagenic, teratogenic, and has no effect on fertility. There have been studies on carcinogenesis and that levocarnitine is a natural constituent of the human.
DOSAGE AND ADMINISTRATION:
The recommended dose is 50 mg / kg per day divided into 2 or 3 doses, but can be increased or decreased based on clinical response and physician discretion. Generally, adults are administered in 3 to 5 g daily, whereas in children, half of the adult dose. Primary impairments in children with levocarnitine, 100 mg / kg body weight per day are used.
MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION
It has not been informed about the presence of overdoses with this product.
PRESENTATIONS:
Box with 20 tablets; Each tablet contains 1 g of levocarnitine. As each tablet contains 1.8 excipient gd compressible sugar equivalent to 7.2 calories.
STORAGE RECOMMENDATIONS
Store at room temperature to no more than 30 ° C and dry temperature.
LEGENDS OF PROTECTION
Keep out of reach of children. Its sale requires a prescription. Exclusively for medical literature.
LABORATORY:
GROSSMAN LABORATORIES, SA
- Drug Name: Cardispan
- Comparable Patent Medicines: Cardispan
- Active ingredient: levocarnitine
- Presentation: Tablets
- Concentration: 1G
- Extended release tablets: No
- Laboratory GROSSMAN
- PACK OF 20 TABLETS
- Made In: Mexico
